Celebrating macromolecular crystallography: A personal perspective
DOI:
https://doi.org/10.3989/arbor.2015.772n2001Keywords:
crystallographic education, crystallography, history of macromolecular crystallography, international year of crystallography, origins of virus crystallography, Spanish education, Spanish researchAbstract
The twentieth century has seen an enormous advance in the knowledge of the atomic structures that surround us. The discovery of the first crystal structures of simple inorganic salts by the Braggs in 1914, using the diffraction of X-rays by crystals, provided the critical elements to unveil the atomic structure of matter. Subsequent developments in the field leading to macromolecular crystallography are presented with a personal perspective, related to the cultural milieu of Spain in the late 1950’s. The journey of discovery of the author, as he developed professionally, is interwoven with the expansion of macromolecular crystallography from the first proteins (myoglobin, hemoglobin) to the ‘coming of age’ of the field in 1971 and the discoveries that followed, culminating in the determination of the structure of the ribosomes at the turn of the century. A perspective is presented exploring the future of the field and also a reflection about the future generations of Spanish scientists.
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Abad-Zapatero, C., Abdel-Meguid, S. S., Johnson, J. E., Leslie, A. G. W., Rayment, I. Rossmann, M. G., Suck, D. and Tsukihara, T. (1980). Structure of southern bean mosaic virus at 2.8 Å resolution. Nature, 286, pp. 33-39.
Abad-Zapatero, C., Griffith, J. P., Sussman J. L. and Rossmann, M. G. (1987). Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. Journal of Molecular Biology, 198, pp. 445-467. http://dx.doi.org/10.1016/0022-2836(87)90293-2
Abad-Zapatero C., Goldman, R., Muchmore, S. W., Hutchins, Ch., Stewart, K., Navaza, J., Payne, C. D. and Ray, T. L. (1996). Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents. Protein Science, 5, 4, pp. 640-652.
Abad-Zapatero, C. (2002a). Crystals and Life: A Personal Journey. La Jolla, CA: International University Line.
Abad-Zapatero, C. (2002b). Protein Crystallography is Dead: Long Live Protein Crystallography. Zeitschrift fu.r Kristallographie, 217, pp. 1-3.
Abad-Zapatero, C. (2005). Notes of a Protein Crystallographer: My nights with ACTOR. Acta Crystallographica, D61, pp. 1432-1435. http://dx.doi.org/10.1107/S090744490502473X PMid:16204898
Abad-Zapatero, C., Perišić, O., Wass, J., Bento, A. P., Overington, J., Al-Lazinkani, B. and Johnson, M. E. (2010). Ligand efficiency indices for an effective mapping of chemico-biological space: the concepts of an atlas-like representation. Drug Discovery Today, 15, pp. 804-811. http://dx.doi.org/10.1016/j.drudis.2010.08.004 PMid:20727982
Abad-Zapatero, C. (2011). Notes of a Protein Crystallographer – Cold Spring Harbor Meeting in 1971 revisited: a commemoration of the birth of the Protein Data Bank (PDB40). ACA RefleXions, 4, pp. 24-25.
Abad-Zapatero, C. (2012). Notes of a Protein Crystallographer: On the high resolution of the PDB deposition rates. Acta Crystallographica, D68. pp. 613-617. http://dx.doi.org/10.1107/S0907444912004799 PMid:22525759
Abad-Zapatero, C. (2013a). Poema a la estructura de un virus. Ballad of the 2.8 Å Structure of SBMV. Virología, 16, 3, pp. 66-69.
Abad-Zapatero. C. (2013b). Ligand Efficiency Indices for Drug Discovery. Towards an Atlas-Guided Paradigm. Academic Press.
Abad-Zapatero, C. (2014). Notes of a Protein Crystallographer: The Beauty of the Rose Windows and the different meanings of Symmetry. Acta Crystallographica, D70, pp. 907-911. http://dx.doi.org/10.1107/S1399004713032859 PMid:24598759
Authier, A. (2014). Early Days of X-ray Crystallography. Oxford: Oxford University Press.
Bernal, J. D. and Crowfoot, D. (1934). X-ray Photographs of Crystalline Pepsin. Nature, 133, pp. 794-795. http://dx.doi.org/10.1038/133794b0
Cabrera, B. (1915a). Estado actual de la teoría de los rayos X y γ: su aplicación al estudio de la estructura de la materia. Anales de la Sociedad Española de Física y Química, 13, 7. Part I. Sections 1-16, pp. 7-30.
Cabrera, B. (1915b). Estado actual de la teoría de los rayos X y γ: su aplicación al estudio de la estructura de la materia. Anales de la Sociedad Española de Física y Química, 13, 7. Part II. Sections 17-29, pp. 63-87.
Cabrera, B. (1915c). Estado actual de la teoría de los rayos X y γ: su aplicación al estudio de la estructura de la materia. Anales de la Sociedad Española de Física y Química, 13, 7. Part III. Sections 30-47, pp. 129-172.
Cabrera, B. (1915d). Estado actual de la teoría de los rayos X y γ: su aplicación al estudio de la estructura de la materia. Anales de la Sociedad Española de Física y Química, 13, 7. Part IV. Sections. 48-73. pp. 184-235.
Cortés-Cabrera, A., Morreale, A., Gago, F. and Abad-Zapatero, C. (2012). AtlasCBS: a web server to map and explore chemico-biological space. Journal of Computer-Aided Molecular Design, 26, pp. 995-1003. http://dx.doi.org/10.1007/s10822-012-9587-5 PMid:22798082
Cortijo-Mérida, M. (2011). Veinticinco Años de la Sociedad de Biofisica de España (1986-2011). Murcia, pp. 30-31.
Ewald, P. (ed.) (1962). Fifty Years of X-ray Diffraction. Utrecht: International Union of Crystallography. http://dx.doi.org/10.1007/978-1-4615-9961-6
Gallo, M. (1972). Historia de la Universidad Española. En Historia de la España franquista. París: Ruedo Ibérico.
García-Ruiz, J. M. (2005). El papel de la cristalografía en los estudios de Historia Natural. Boletín de la Real Sociedad Española de Historia Natural (Sección Geológica), 100, pp. 25-37.
Garrido, J. y Orland, J. (1946). Los rayos X y la estructura fina de los cristales; fundamentos teóricos y métodos prácticos. Madrid: Dossat.
Jones, T. A. (1978). FRODO: A graphics model building and refinement system for macromolecules. Journal of Applied Crystallography, 11, p. 268. http://dx.doi.org/10.1107/S0021889878013308
Kay, L. E. (1986). W. M. Stanley's Crystallization of the Tobacco Mosaic Virus, 1930-1940. Isis, 77, 3, pp. 450-472.
Li, L., Lok, S-M., Yu, I-M., Zhang, Y., Kuhn, R. J., Chen, J. and Rossmann, M. G. (2008). The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science, 319, pp: 1830-1834.
Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E., Rossmann, M. G., Boege, U., Scraba, D. G., Duke, G. M. and Palmenberg, A. C. (1987). The atomic structure of Mengo virus at 3.0 Å resolution. Science, 235, pp. 182-191.
Pardillo, F. (1913). Descubrimientos recientes sobre la estructura de los cristales. Boletín de la Real Sociedad de Historia Natural, 13, pp. 336-339.
Phillips, D. C. (1966). The Three-dimensional Structure of an Enzyme Molecule. Scientific American, 215, pp. 78-90. http://dx.doi.org/10.1038/scientificamerican1166-78 PMid:5978599
Rao, S. T. and Rossmann, M. G. (1973). Comparison of super-secondary structures in proteins. Journal of Molecular Biology, 76, pp. 241-256. http://dx.doi.org/10.1016/0022-2836(73)90388-4
Ridley, M. (2006). Francis Crick. Discoverer of the Genetic Code. New York: Harper Collins Publishers.
Rossmann, M. G. (1979). Processing oscillation diffraction data for very large unit cells with an automatic convolution technique and profile fitting. Journal of Applied Crystallography, 12, pp. 225-238. http://dx.doi.org/10.1107/S0021889879012218
Rossmann, M. G. and Erickson, J. W. (1983). Oscillation photography of radiation-sensitive crystals using a synchrotron source. Journal of Applied Crystallography, 16, pp. 629-636. http://dx.doi.org/10.1107/S002188988301119X
Rossmann, M. G., Arnold, E., Erickson, J. W., Frankerberger, E. A., Griffith, J. P., Hecht, H. J., Johnson, J. E., Kamer, G., Luo, M. and Moser, A. G. (1985). Structure of a human common cold virus and functional relationship to other picornaviruses. Nature, 317, pp. 145-153. http://dx.doi.org/10.1038/317145a0 PMid:2993920
Rossmann, M. G. (2014). Selected Papers of Michael G. Rossmann with Commentaries. The development of Structural Biology. London: World Scientific.
Setlow, R. B. and Pollard, E. C. (1962). Molecular Biophysics. London and Palo Alto: Addison-Wesley.
Stanley, W. M. (1935). Isolation of a crystalline protein possessing the properties of tobacco-mosaic virus. Science, 81, pp. 2113-2114. http://dx.doi.org/10.1126/science.81.2113.644 PMid:17743301
Watson, J. (coord.) (1971). Structure and Function of Proteins at the Three-Dimensional Level. Cold Spring Harbor Symposia on Quantitative Biology, XXXVI.
Yonath, A., Müssig, J., Tesche, B., Lorenz, S., Erdmann, V. A. and Wittmann, H. G. (1980). Crystallization of the large ribosomal subunit from B. stearothermophilus. Biochemistry International, 1, pp. 315-428.
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