Gender-related biological differences in cancer
DOI:
https://doi.org/10.3989/arbor.2015.773n3003Keywords:
estrogens, lung cancer, tobaccoAbstract
Several studies show that women are potentially more susceptible to developing lung cancer (LC). Specifically, women are more prone to adenocarcinomas, they usually develop the disease younger, are diagnosed at earlier stages, and female non-smokers are at higher risk. On the other hand, no particular cause has been detected for all LC, which suggests the presence of additive synergistic effects among several causes, in conjunction with predisposing and risk factors for LC. In line with this, the hypothesis that oestrogens can play a role in LC carcinogenesis is gaining acceptance, although the mechanism by which oestrogens are involved in this process is not clear. Although, on the whole, this review suggests women are more likely to smoke and so potentially more prone to develop LC, the influence of these differential characteristics regarding survival is controversial.
Downloads
References
Cabanes, A., Vidal, E., Aragones, N., Perez-Gomez, B., Pollan, M., Lope, V., et al. (2010). Cancer mortality trends in Spain: 1980-2007. Annals of Oncology, 21, Suppl 3, pp. iii14-20. http://dx.doi.org/10.1093/annonc/mdq089 PMid:20427355
Dogan, S., Shen, R., Ang, D. C., Johnson, M. L., D'Angelo, S. P., Paik, P. K., et al. (2012). Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clinical Cancer Research, 18, 22, pp. 6169-6177. http://dx.doi.org/10.1158/1078-0432.CCR-11-3265 PMid:23014527 PMCid:PMC3500422
Hershberger, P. A., Stabile, L. P., Kanterewicz, B., Rothstein, M. E., Gubish, C. T., Land, S., et al. (2009). Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-small cell lung cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 116, 1-2, pp. 102-109. http://dx.doi.org/10.1016/j.jsbmb.2009.05.004 PMid:19460433 PMCid:PMC2722836
Kiyohara, C. y Ohno, Y. (2010). Sex differences in lung cancer susceptibility: a review. Gender Medicine, 7, 5, pp. 381-401. http://dx.doi.org/10.1016/j.genm.2010.10.002 PMid:21056866 Losordo, D. W. e Isner, J. M. (2001). Estrogen and angiogenesis: A review. Arteriosclerosis, Thrombosis and Vascular Biology, 21, 1, pp. 6-12. http://dx.doi.org/10.1161/01.ATV.21.1.6
Marrogi, A. J., Mechanic, L. E., Welsh, J. A., Bowman, E. D., Khan, M. A., Enewold, L., et al. (2005). TP53 mutation spectrum in lung cancer is not different in women and men. Cancer Epidemiology, Biomarkers and Prevention, 14, 4, pp. 1031-1033. http://dx.doi.org/10.1158/1055-9965.EPI-04-0640 PMid:15824188 Matthews, J. y Gustafsson, J. A. (2003). Estrogen signaling: a subtle balance between ER alpha and ER beta. Molecular Interventions, 3, 5, pp. 281-292. http://dx.doi.org/10.1124/mi.3.5.281 PMid:14993442
Morani, A., Warner, M. y Gustafsson, J. A. (2008). Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues. Journal of Internal Medicine, 264, 2, pp. 128-142. http://dx.doi.org/10.1111/j.1365-2796.2008.01976.x PMid:18513343
Patrone, C., Cassel, T. N., Pettersson, K., Piao, Y. S., Cheng, G., Ciana, P., et al. (2003). Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Molecular and Cellular Biology, 23, 23, pp. 8542-8552. http://dx.doi.org/10.1128/MCB.23.23.8542-8552.2003 PMCid:PMC262653
Pesatori, A. C., Carugno, M., Consonni, D., Caporaso, N. E., Wacholder, S., Tucker, M., et al. (2013). Reproductive and hormonal factors and the risk of lung cancer: the EAGLE study. International Journal of Cancer, 132, 11, pp. 2630-2639. http://dx.doi.org/10.1002/ijc.27926 PMid:23129166 PMCid:PMC3609937
Stabile, L. P., Dacic, S., Land, S. R., Lenzner, D. E., Dhir, R., Acquafondata, M., et al. (2011). Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome. Clinical Cancer Research, 17, 1, pp. 154-164. http://dx.doi.org/10.1158/1078-0432.CCR-10-0992 PMid:21062926 PMCid:PMC3064257
Wu, C. T., Chang, Y. L., Shih, J. Y. y Lee, Y. C. (2005). The significance of estrogen receptor beta in 301 surgically treated non-small cell lung cancers. Journal of Thoracic and Cardiovascular Surgery, 130, 4, pp. 979-986. http://dx.doi.org/10.1016/j.jtcvs.2005.06.012 PMid:16214508
Zang, E. A. y Wynder, E. L. (1996). Differences in lung cancer risk between men and women: examination of the evidence. Journal of the National Cancer Institute, 88, 3-4, pp. 183-192. http://dx.doi.org/10.1093/jnci/88.3-4.183
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 Consejo Superior de Investigaciones Científicas (CSIC)
This work is licensed under a Creative Commons Attribution 4.0 International License.
© CSIC. Manuscripts published in both the printed and online versions of this Journal are the property of Consejo Superior de Investigaciones Científicas, and quoting this source is a requirement for any partial or full reproduction.
All contents of this electronic edition, except where otherwise noted, are distributed under a “Creative Commons Attribution 4.0 International” (CC BY 4.0) License. You may read the basic information and the legal text of the license. The indication of the CC BY 4.0 License must be expressly stated in this way when necessary.
Self-archiving in repositories, personal webpages or similar, of any version other than the published by the Editor, is not allowed.
