Stem cell research and scientific creativity
DOI:
https://doi.org/10.3989/arbor.2019.792n2006Keywords:
Embryonic Stem Cells, induced pluripotent Stem Cells, Cell therapy, Nuclear Transfer, therapeutic cloning, scientific rationality and ethics, creative thinkingAbstract
Human Embryonic Stem Cells were discovered in 1998 and many speculations arose about their therapeutic possibilities, motivated by ideological, political and economic aspects. The difficulties were insurmountable. However, induced Pluripotent Stem Cells appeared in 2007 and this research trajectory showed key aspects of creative thinking. a) Motivation ethics to find a nondestructive starting point to mark the rationality of that way: the physiological processes occur within the unit of an organism. b) A thorough knowledge of the scientific experience to choose the most natural way. c) Future vision exhausting possibilities offered by animal testing and finding useful applications for the knowledge obtained. d) Responsibility for the consequences.
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Aiba, K., Nedorezov, T., Piao, Y., Nishiyama, A., Matoba, R., Sharova, L. V. […] y Ko, M. S. (2009). Defining Developmental Potency and Cell Lineage Trajectories by Expression Profiling of Differentiating Mouse Embryonic Stem Cells. DNA Research, 16 (1), pp. 73-80. https://doi.org/10.1093/dnares/dsn035 PMid:19112179 PMCid:PMC2644347
Beaty R. E., Benedek, M., Silvia, P. J. y Schacter D. L. (2016). Creative Cognition and Brain Network Dynamics. Trends in Cognitive Sciences, 20 (2), pp. 87-95. https://doi.org/10.1016/j.tics.2015.10.004 PMid:26553223 PMCid:PMC4724474
Cyranoski, D. (2012). Stem-cell pioneer banks on future therapies. Nature News, 488 (7410), 139. https://doi.org/10.1038/488139a PMid:22874941
Daley, G. (2010). Stem cells: roadmap to the clinic. The Journal of Clinical Investigation, 120 (1), pp. 8-10. https://doi.org/10.1172/JCI41801 PMid:20051631 PMCid:PMC2798707
Ebert, A. D., Yu, J., Rose, F. F., Mattis, V. B., Lorson, C. L., Thomson, J. A. Y Svendsen, C. N. (2009). Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature, 457 (7227), pp. 51-61. https://doi.org/10.1038/nature07677 PMid:19098894 PMCid:PMC2659408
Gurdon, J. B. (1962). The transplantation of nuclei between two species of Xenopus. Developmental Biology, 5 (1), pp. 68-83. https://doi.org/10.1016/0012-1606(62)90004-0
Gurdon, J., Byrne, J. A. y Simonsson, S. (2003). Nuclear reprogramming and stem cell creation. Proceedings of the National Academy of Sciences, 100 (suppl. 1), pp. 11819- 11822. https://doi.org/10.1073/pnas.1834207100 PMid:12920185 PMCid:PMC304092
Hanna, J., Wernig, M., Markoulaki, S., Sun, C.W., Meissner, A., Cassady, J. P. […] Jaenisch, R. (2007). Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin. Science, 318 (5858), pp. 1920- 1923. https://doi.org/10.1126/science.1152092 PMid:18063756
Hayashi, Y., Saitou, M. y Yamanaka, S. (2012). Germline development from human pluripotent stem cells toward disease modeling of infertility. Fertility and Sterility, 97 (6), pp. 1250- 1259. https://doi.org/10.1016/j.fertnstert.2012.04.037 PMid:22656305
Herranz, G. (2013). The timing of monozygotic twinning: a criticism of the common model. Zygote, 21 (3), pp. 1-14. https://doi.org/10.1017/S0967199413000257 PMid:23735171
Inagawa, K., Miyamoto, K., Yamakawa, H., Muraoka, N., Sadahiro T, Umei, T. […] y Kurihara, C. (2012). Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5. Circulation Research, 111 (9), pp. 1147-1156. https://doi.org/10.1161/CIRCRESAHA.112.271148 PMid:22931955
Isner, J. M., Pieczek, A., Schainfeld, R., Blair, R., Haley, L. Asahara, T. […] Symes, J. F. (1996). Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. The Lancet, 348 (9024), pp. 370- 374. https://doi.org/10.1016/S0140-6736(96)03361-2
Jessup, M., Greenberg, B., Mancini, D., Cappola, T., Pauly, D. F., Jaski, B. [...] y Hajjar, R. J. (2011). Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID). A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients with Advanced Heart Failure. Circulation, 124 (3), pp. 304-313. https://doi.org/10.1161/CIRCULATIONAHA.111.022889 PMid:21709064 PMCid:PMC5843948
Junying, Y., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S. [...] y Thomson, J. A. (2007). Induced Pluripotent Stem Cell Lines Derived from Somatic Cells. Science, 318 (5858), pp. 1917-1920. https://doi.org/10.1126/science.1151526 PMid:18029452
Kawakami, M., Sipp, D. y Kato, K. (2010). Regulatory Impacts on Stem Cell Research in Japan. Cell Stem Cell, 6 (5), pp. 415-418. https://doi.org/10.1016/j.stem.2010.04.010 PMid:20452315
López Moratalla, N. (2004). Uso terapéutico con células troncales humanas: racionalidad científica. Cuadernos de Bioética, 53, pp. 77-97.
López Moratalla, N. (2005). El lobby de las células embrionarias. Telón de fondo del fraude de la clonación. Cuadernos de Bioética, 58, pp. 419-439.
López Moratalla, N. (2007). Células troncales rejuvenecidas y el final de la clonación. Cuadernos de Bioética, 64, pp. 387-392.
López Moratalla, N. (2009). ¿Resucitan al inicio del 2009 las células troncales procedentes de embriones? Cuadernos de Bioética, 70, pp. 471-486.
Losordo, D. W., Vale, P. R., Symes, J. F., Dunnington, C. H., Esakof, D. D., Maysky, M. […] e Isner, J. M. (1998). Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation, 98 (25), pp. 2800-2804. https://doi.org/10.1161/01.CIR.98.25.2800 PMid:9860779
Park, I. H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A. […] y Daley, G. Q. (2008). Disease-Specific Induced Pluripotent Stem Cells. Cell, 134 (5), pp. 877-886. https://doi.org/10.1016/j.cell.2008.07.041 PMid:18691744 PMCid:PMC2633781
Pera, M. F. (2011). Stem cells: The dark side of induced pluripotency. Nature, 471 (7336), pp. 46-47. https://doi.org/10.1038/471046a PMid:21368819
Petryna, A. (2011). The Competitive Logic of Global Clinical Trials. Social Research. An International Quarterly, 78 (3), pp. 949-974.
Philonenko, E. S., Shutova, M. V., Chestkov, l. V., Lagarkova, M. A. y Kiselev, S. L. (2011). Current Progress and Potential Practical Application for Human Pluripotent Stem Cells. International Review of Cell and Molecular Biology, 292, pp. 153-196. https://doi.org/10.1016/B978-0-12-386033-0.00004-9 PMid:22078961
Qian, L., Huang, Y., Spencer, C. I., Foley, A., Vedantham, V., Liu, L. […] y Srivastava. D. (2012). In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature, 485 (7400), pp. 593-598. https://doi.org/10.1038/nature11044 PMid:22522929 PMCid:PMC3369107
Rugg-Gunn, P. J., Ferguson-Smith, A. C. y Pedersen, R. A. (2007). Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines. Human Molecular Genetics, 16 (R2), pp. R243-R251. https://doi.org/10.1093/hmg/ddm245 PMid:17911167
Sadahiro, T., Yamanaka, S. y Ieda, M. (2015). Direct Cardiac Reprogramming: Progress and Challenges in Basic Biology and Clinical Applications. Circulation Research, 116 (8), pp. 1378-1391. https://doi.org/10.1161/CIRCRESAHA.116.305374 PMid:25858064
Schwartz, S. D., Regillo, C. D., Lam, B. L., Eliott, D., Rosenfeld, P. J., Gregori, N. Z. […] Maguire, J. (2014). Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. The Lancet, 385 (9967), pp. 509- 516. https://doi.org/10.1016/S0140-6736(14)61376-3
Sims, R. J. y Reinberg, D. (2009). Stem cells: Escaping fates with open states. Nature, 460 (7257), pp. 802-803. https://doi.org/10.1038/460802a PMid:19675633
Tachibana, M., Amato, P., Sparman, M., Gutierrez, N. M., Tippner-Hedges, R., Ma, H. […] y Masterson, K. (2013). Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer. Cell, 153 (6), pp. 1228-1238. https://doi.org/10.1016/j.cell.2013.05.006 PMid:23683578 PMCid:PMC3772789
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. y Yamanaka, S. (2007). Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell, 131 (5), pp. 861-872. https://doi.org/10.1016/j.cell.2007.11.019 PMid:18035408
Takahashi, K. y Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126 (4), pp. 663-676. https://doi.org/10.1016/j.cell.2006.07.024 PMid:16904174
Taura, D., Noguchi, M., Sone, M., Hosoda, K., Mori, E., Okada, Y. [...] y Sonoyama, T. (2009). Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Letters, 583 (6), pp. 1029-1033. https://doi.org/10.1016/j.febslet.2009.02.031 PMid:19250937
Yamanaka, S. (2009a). A Fresh Look at iPS Cells. Cell, 137 (1), pp. 13-17. https://doi.org/10.1016/j.cell.2009.03.034 PMid:19345179
Yamanaka, S. (2009b). Elite and stochastic models for induced pluripotent stem cell generation. Nature, 460 (7251), pp. 49- 52. https://doi.org/10.1038/nature08180 PMid:19571877
Yamanaka, S. (2010). Patient-Specific Pluripotent Stem Cells Become Even More Accessible. Cell Stem Cell, 7 (1), pp. 1-2. https://doi.org/10.1016/j.stem.2010.06.009 PMid:20621038
Yamanaka, S. y Blau, H. M. (2010). Nuclear reprogramming to a pluripotent state by three approaches. Nature, 465 (7299), pp. 704-712. https://doi.org/10.1038/nature09229 PMid:20535199 PMCid:PMC2901154
Yoshida, Y. y Yamanaka, S. (2012). An Emerging Strategy of Gene Therapy for Cardiac Disease. Circulation Research, 111 (9), pp. 1108-1110. https://doi.org/10.1161/CIRCRESAHA.112.278820 PMid:23065338
Zacharias, D. G., Nelson, T. J., Mueller, P. S. y Hook, C. (2011). The science and ethics of induced pluripotency: what will become of enbryonic stem cells? Mayo Clinic Proceedings, 86 (7), pp. 634-640. https://doi.org/10.4065/mcp.2011.0054 PMid:21719620 PMCid:PMC3127559
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P. […] y Kamp, T. J. (2009). Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells. Circulation Research, 104 (4), pp. e30-e41. https://doi.org/10.1161/CIRCRESAHA.108.192237 PMid:19213953 PMCid:PMC2741334
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. y Melton, D. A. (2008). In vivo reprogramming of adult pancreatic exocrine cells to ?-cells. Nature, 455 (7213), pp. 637-632. https://doi.org/10.1038/nature07314 PMid:18754011
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